Msx1 is required for the induction ofPatched bySonic hedgehog in the mammalian tooth germ
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15 صفحه اولMsx1 controls inductive signaling in mammalian tooth morphogenesis.
Members of the Msx homeobox family are thought to play important roles in inductive tissue interactions during vertebrate organogenesis, but their precise developmental function has been unclear. Mice deficient for Msx1 exhibit defects in craniofacial development and a failure of tooth morphogenesis, with an arrest in molar tooth development at the E13.5 bud stage. Because of its potential for ...
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The dorsal midline of the neural tube has recently emerged as a major signaling center for dorsoventral patterning. Msx genes are expressed at the dorsal midline, although their function at this site remains unknown. Using Msx1(nlacZ) mutant mice, we show that the normal expression domain of Msx1 is interrupted in the pretectum of mutant embryos. Morphological and gene expression data further i...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1999
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199905)215:1<45::aid-dvdy5>3.0.co;2-5